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Research Associate II - Biochemistry & Molecular Pharm
Job Number: 2020-36199Category: Research
Location: Worcester, MA
Shift: Day
Exempt/Non-Exempt: Exempt
Business Unit: UMass Chan Medical School
Department: School - Biochemistry & Molecular Pharm - W404000
Job Type: Full-Time
Salary Grade: 44
Union Code: Non Union Position -W60- Non Unit Professional
Num. Openings: 1
Post Date: Jan. 29, 2021
POSITION SUMMARY:
Under the general direction of the Principle Investigator, the Research Associate II performs a variety of research experiments on a range of biochemical (enzymatic), biophysical and structural biology (x-ray; Cryo-EM) characterization of proteins pertinent to the interests of the research programs of the laboratory.
ESSENTIAL FUNCTIONS:
Research:
- Design and implement experiments to further ongoing research projects, in consultation with the principal investigator.
- Responsible for data acquisition, data analysis, and presentation of research results.
- Organize and analyze data acquired in the course of research projects.
- Prepare and present data for publication in public forums.
- Specific expertise in the study of enzymes is required including:
- Preparation of large milligram quantities of purified proteins that are amenable to protein crystallography.
- Engineering proteins to optimize expression and probe specific aspects of activity.
- Designing and optimizing well controlled enzymatic assays – including acquiring, processing, analyzing and preparing for public presentation (grants/seminars/articles) the data.
- Measuring kcat / Km and Kd by kinetic (fluorescent anisotropy) or thermodynamic (isothermal titration calorimetry) assays.
- Crystallization of apo and liganded proteins – with either substrates or inhibitors that are of quality for crystallographic studies.
Mentorship:
- Train and supervise junior lab personnel, ensuring staff is trained in current methodology and safety procedures in the laboratory.
- Participate regularly in laboratory meetings.
- Provide support for under-represented minorities scholars.
- Ensure researchers in the laboratory are aware of the experimental nuances and potential risks of their experiments – that they are using the optimal approach to obtain quality data.
- Coordinate the protein expression - crystallization efforts with regard to the various ongoing projects in the lab.
Laboratory Operations:
- Lead and coordinate the general operation of the laboratory.
- Maintaining records and samples of generated lab reagents: strains, plasmids, proteins and data.
- Maintain standard operating procedure of laboratory protocols and best practices.
- Run the lab in a positive supportive manner.
- Daily ordering of supplies, organizing lab supplies.
- Interface with vendors both around purchases and service contracts.
- Perform routine maintenance on specialized laboratory equipment and interface with vendors.
- Provide Departmental Support for shared instrumentation (ITC) and as part of the Structure Based Drug Design Core.
- Interface with collaborators across the University and around the Country.
- Perform other duties as required.
REQUIRED QUALIFICATIONS:
- Bachelor’s degree in a Biological Science, or equivalent degree
- 5 years of research experience.
- Familiarity with general laboratory procedures.
- Expertise in specific procedures and instrumentation necessary to complete specific research programs.
- Current knowledge of pertinent literature.
- Oral and written communication and presentation skills
- Ability to travel to off-site locations