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Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nat Biotechnol. 2024 Apr;42(4):597-607. doi: 10.1038/s41587-023-01840-6. Epub 2023 Aug 3. PubMed PMID: 37537499; PubMed Central PMCID: PMC11018308.
Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Smith CM, Li A, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Judy Shon D, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Lemmon MA, Amaro RE, Malaker SA. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. Nat Commun. 2023 Oct 4;14(1):6169. doi: 10.1038/s41467-023-41756-y. PubMed PMID: 37794035; PubMed Central PMCID: PMC10550946.
Shon DJ, Fernandez D, Riley NM, Ferracane MJ, Bertozzi CR. Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences. J Biol Chem. 2022 May;298(5):101917. doi: 10.1016/j.jbc.2022.101917. Epub 2022 Apr 9. PubMed PMID: 35405095; PubMed Central PMCID: PMC9118916.
Shon DJ, Kuo A, Ferracane MJ, Malaker SA. Classification, structural biology, and applications of mucin domain-targeting proteases. Biochem J. 2021 Apr 30;478(8):1585-1603. doi: 10.1042/BCJ20200607. Review. PubMed PMID: 33909028.
Gisemba SA, Ferracane MJ, Murray TF, Aldrich JV. Conformational Constraint between Aromatic Residue Side Chains in the "Message" Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist. J Med Chem. 2021 Mar 25;64(6):3153-3164. doi: 10.1021/acs.jmedchem.0c01984. Epub 2021 Mar 10. PubMed PMID: 33688737; NIHMSID:NIHMS1683814.
Haurat MF, Scott NE, Di Venanzio G, Lopez J, Pluvinage B, Boraston AB, Ferracane MJ, Feldman MF. The Glycoprotease CpaA Secreted by Medically Relevant Acinetobacter Species Targets Multiple O-Linked Host Glycoproteins. mBio. 2020 Oct 6;11(5). doi: 10.1128/mBio.02033-20. PubMed PMID: 33024038; PubMed Central PMCID: PMC7542363.
Brice-Tutt AC, Wilson LL, Eans SO, Stacy HM, Simons CA, Simpson GG, Coleman JS, Ferracane MJ, Aldrich JV, McLaughlin JP. Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour. Br J Pharmacol. 2020 Sep;177(18):4209-4222. doi: 10.1111/bph.15165. Epub 2020 Jul 16. PubMed PMID: 32562259; PubMed Central PMCID: PMC7443475.
Ferracane MJ, Brice-Tutt AC, Coleman JS, Simpson GG, Wilson LL, Eans SO, Stacy HM, Murray TF, McLaughlin JP, Aldrich JV. Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist-Antagonist Following Oral Administration. ACS Chem Neurosci. 2020 May 6;11(9):1324-1336. doi: 10.1021/acschemneuro.0c00086. Epub 2020 Apr 21. PubMed PMID: 32251585; NIHMSID:NIHMS1678142.
Malaker SA, Pedram K, Ferracane MJ, Bensing BA, Krishnan V, Pett C, Yu J, Woods EC, Kramer JR, Westerlind U, Dorigo O, Bertozzi CR. The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7278-7287. doi: 10.1073/pnas.1813020116. Epub 2019 Mar 25. PubMed PMID: 30910957; PubMed Central PMCID: PMC6462054.
Malaker SA, Ferracane MJ. Mass Spectrometric Identification and Molecular Modeling of Glycopeptides Presented by MHC Class I and II Processing Pathways. Methods Mol Biol. 2019;2024:269-285. doi: 10.1007/978-1-4939-9597-4_17. PubMed PMID: 31364056.
Malaker SA, Ferracane MJ, Depontieu FR, Zarling AL, Shabanowitz J, Bai DL, Topalian SL, Engelhard VH, Hunt DF. Identification and Characterization of Complex Glycosylated Peptides Presented by the MHC Class II Processing Pathway in Melanoma. J Proteome Res. 2017 Jan 6;16(1):228-237. doi: 10.1021/acs.jproteome.6b00496. Epub 2016 Sep 13. PubMed PMID: 27550523; PubMed Central PMCID: PMC5218890.
Lefever MR, Szabò LZ, Anglin B, Ferracane M, Hogan J, Cooney L, Polt R. Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids. Carbohydr Res. 2012 Apr 1;351:121-5. doi: 10.1016/j.carres.2012.01.008. Epub 2012 Jan 28. PubMed PMID: 22342206; PubMed Central PMCID: PMC3296895.
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