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Langston JC, Yang Q, Kiani MF, Kilpatrick LE. LEUKOCYTE PHENOTYPING IN SEPSIS USING OMICS, FUNCTIONAL ANALYSIS, AND IN SILICO MODELING. Shock. 2023 Feb 1;59(2):224-231. doi: 10.1097/SHK.0000000000002047. Epub 2022 Nov 15. Review. PubMed PMID: 36377365; PubMed Central PMCID: PMC9957940.
Langston JC, Rossi MT, Yang Q, Ohley W, Perez E, Kilpatrick LE, Prabhakarpandian B, Kiani MF. Omics of endothelial cell dysfunction in sepsis. Vasc Biol. 2022 Feb 1;4(1):R15-R34. doi: 10.1530/VB-22-0003. eCollection 2022 Feb 1. Review. PubMed PMID: 35515704; PubMed Central PMCID: PMC9066943.
Sun S, Kilpatrick LE, Jensen LE. Transient Induction of Fever in the Imiquimod C57BL/6 Mouse Model of Psoriasis-Like Disease Involves IL-1 and IL-6 but Not IL-36. J Invest Dermatol. 2022 Jan;142(1):247-251.e2. doi: 10.1016/j.jid.2021.05.028. Epub 2021 Jul 17. PubMed PMID: 34280465; PubMed Central PMCID: PMC8688218.
Yang Q, Langston JC, Tang Y, Prabhakarpandian B, Kilpatrick LE, Kiani MF. A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation. J Vis Exp. 2021 Dec 9;(178). doi: 10.3791/63312. PubMed PMID: 34958086.
Yang Q, Wijerathne H, Langston JC, Kiani MF, Kilpatrick LE. Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics. Int J Mol Sci. 2021 Jul 21;22(15). doi: 10.3390/ijms22157770. Review. PubMed PMID: 34360536; PubMed Central PMCID: PMC8346165.
Wijerathne H, Langston JC, Yang Q, Sun S, Miyamoto C, Kilpatrick LE, Kiani MF. Mechanisms of radiation-induced endothelium damage: Emerging models and technologies. Radiother Oncol. 2021 May;158:21-32. doi: 10.1016/j.radonc.2021.02.007. Epub 2021 Feb 11. Review. PubMed PMID: 33581220; PubMed Central PMCID: PMC8119342.
Kilpatrick LE, Kiani MF. Experimental Approaches to Evaluate Leukocyte-Endothelial Cell Interactions in Sepsis and Inflammation. Shock. 2020 May;53(5):585-595. doi: 10.1097/SHK.0000000000001407. PubMed PMID: 32080065; PubMed Central PMCID: PMC7160007.
Soroush F, Tang Y, Mustafa O, Sun S, Yang Q, Kilpatrick LE, Kiani MF. Neutrophil-endothelial interactions of murine cells is not a good predictor of their interactions in human cells. FASEB J. 2020 Feb;34(2):2691-2702. doi: 10.1096/fj.201900048R. Epub 2019 Dec 23. PubMed PMID: 31908006; PubMed Central PMCID: PMC7018548.
Liverani E, Tursi SA, Cornwell WD, Mondrinos MJ, Sun S, Buttaro BA, Wolfson MR, Rogers TJ, Tükel Ç, Kilpatrick LE. Protein kinase C-delta inhibition is organ-protective, enhances pathogen clearance, and improves survival in sepsis. FASEB J. 2020 Feb;34(2):2497-2510. doi: 10.1096/fj.201900897R. Epub 2019 Dec 23. PubMed PMID: 31908004; PubMed Central PMCID: PMC7568544.
Soroush F, Tang Y, Guglielmo K, Engelmann A, Liverani E, Patel A, Langston J, Sun S, Kunapuli S, Kiani MF, Kilpatrick LE. Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation. Shock. 2019 May;51(5):538-547. doi: 10.1097/SHK.0000000000001247. PubMed PMID: 30095599; PubMed Central PMCID: PMC6367064.
Yang Q, Langston JC, Tang Y, Kiani MF, Kilpatrick LE. The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation. Int J Mol Sci. 2019 Mar 26;20(6). doi: 10.3390/ijms20061498. Review. PubMed PMID: 30917487; PubMed Central PMCID: PMC6471617.
Tang Y, Soroush F, Sun S, Liverani E, Langston JC, Yang Q, Kilpatrick LE, Kiani MF. Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage. J Neuroinflammation. 2018 Nov 6;15(1):309. doi: 10.1186/s12974-018-1342-y. PubMed PMID: 30400800; PubMed Central PMCID: PMC6220469.
Soroush F, Tang Y, Zaidi HM, Sheffield JB, Kilpatrick LE, Kiani MF. PKCδ inhibition as a novel medical countermeasure for radiation-induced vascular damage. FASEB J. 2018 Jun 13;:fj201701099. doi: 10.1096/fj.201701099. [Epub ahead of print] PubMed PMID: 29897816.
Liverani E, Mondrinos MJ, Sun S, Kunapuli SP, Kilpatrick LE. Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. PLoS One. 2018;13(4):e0195379. doi: 10.1371/journal.pone.0195379. eCollection 2018. PubMed PMID: 29617417; PubMed Central PMCID: PMC5884571.
Zheng X, Soroush F, Long J, Hall ET, Adishesha PK, Bhattacharya S, Kiani MF, Bhalla V. Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy. PLoS One. 2017;12(9):e0185250. doi: 10.1371/journal.pone.0185250. eCollection 2017. PubMed PMID: 28934365; PubMed Central PMCID: PMC5608371.
Tang Y, Soroush F, Sheffield JB, Wang B, Prabhakarpandian B, Kiani MF. A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems. Sci Rep. 2017 Aug 24;7(1):9359. doi: 10.1038/s41598-017-09815-9. PubMed PMID: 28839211; PubMed Central PMCID: PMC5571192.
Cheheltani R, Pichamuthu JE, Rao J, Weinbaum JS, Kiani MF, Vorp DA, Pleshko N. Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients. Cardiovasc Eng Technol. 2017 Mar;8(1):70-80. doi: 10.1007/s13239-016-0289-3. Epub 2016 Dec 19. PubMed PMID: 27995569.
Tang Y, Soroush F, Tong Z, Kiani MF, Wang B. Targeted multidrug delivery system to overcome chemoresistance in breast cancer. Int J Nanomedicine. 2017;12:671-681. doi: 10.2147/IJN.S124770. eCollection 2017. PubMed PMID: 28176940; PubMed Central PMCID: PMC5268372.
Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF. A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. J Leukoc Biol. 2016 Nov;100(5):1027-1035. doi: 10.1189/jlb.3MA0216-087R. Epub 2016 May 17. PubMed PMID: 27190303; PubMed Central PMCID: PMC5069089.
Tang Y, Wang Y, Kiani MF, Wang B. Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer. Clin Breast Cancer. 2016 Oct;16(5):335-343. doi: 10.1016/j.clbc.2016.05.012. Epub 2016 May 13. Review. PubMed PMID: 27268750.
Deosarkar SP, Prabhakarpandian B, Wang B, Sheffield JB, Krynska B, Kiani MF. A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip. PLoS One. 2015;10(11):e0142725. doi: 10.1371/journal.pone.0142725. eCollection 2015. PubMed PMID: 26555149; PubMed Central PMCID: PMC4640840.
Hemmasizadeh A, Tsamis A, Cheheltani R, Assari S, D'Amore A, Autieri M, Kiani MF, Pleshko N, Wagner WR, Watkins SC, Vorp D, Darvish K. Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta. J Mech Behav Biomed Mater. 2015 Jul;47:12-20. doi: 10.1016/j.jmbbm.2015.03.004. Epub 2015 Mar 19. PubMed PMID: 25837340; PubMed Central PMCID: PMC4430388.
Tang Y, Wang Y, Deosarkar S, Soroush F, Kiani MF, Wang B. Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene. Anticancer Res. 2015 May;35(5):2531-8. PubMed PMID: 25964526.
Lamberti G, Soroush F, Smith A, Kiani MF, Prabhakarpandian B, Pant K. Adhesion patterns in the microvasculature are dependent on bifurcation angle. Microvasc Res. 2015 May;99:19-25. doi: 10.1016/j.mvr.2015.02.004. Epub 2015 Feb 21. PubMed PMID: 25708050; PubMed Central PMCID: PMC4426015.
Tang Y, Gan X, Cheheltani R, Curran E, Lamberti G, Krynska B, Kiani MF, Wang B. Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model. Nanomedicine. 2014 Nov;10(8):1711-8. doi: 10.1016/j.nano.2014.06.001. Epub 2014 Jun 15. PubMed PMID: 24941463; PubMed Central PMCID: PMC4253977.
Lamberti G, Prabhakarpandian B, Garson C, Smith A, Pant K, Wang B, Kiani MF. Bioinspired microfluidic assay for in vitro modeling of leukocyte-endothelium interactions. Anal Chem. 2014 Aug 19;86(16):8344-51. doi: 10.1021/ac5018716. Epub 2014 Aug 5. PubMed PMID: 25135319; PubMed Central PMCID: PMC4139165.
Cheheltani R, McGoverin CM, Rao J, Vorp DA, Kiani MF, Pleshko N. Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta. Analyst. 2014 Jun 21;139(12):3039-47. doi: 10.1039/c3an02371k. Epub 2014 Apr 24. PubMed PMID: 24761431; PubMed Central PMCID: PMC4096121.
Lamberti G, Tang Y, Prabhakarpandian B, Wang Y, Pant K, Kiani MF, Wang B. Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks. Microvasc Res. 2013 Sep;89:107-14. doi: 10.1016/j.mvr.2013.03.007. Epub 2013 Apr 2. PubMed PMID: 23557880.
Wang B, Cheheltani R, Rosano J, Crabbe DL, Kiani MF. Targeted delivery of VEGF to treat myocardial infarction. Adv Exp Med Biol. 2013;765:307-314. doi: 10.1007/978-1-4614-4989-8_43. PubMed PMID: 22879049.
Rosano JM, Cheheltani R, Wang B, Vora H, Kiani MF, Crabbe DL. Targeted Delivery of VEGF after a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function. Cardiovasc Eng Technol. 2012 Jun;3(2):237-247. doi: 10.1007/s13239-012-0089-3. PubMed PMID: 22844388; PubMed Central PMCID: PMC3405981.
Venegas B, Zhu W, Haloupek NB, Lee J, Zellhart E, Sugár IP, Kiani MF, Chong PL. Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells. Biophys J. 2012 May 2;102(9):2086-94. doi: 10.1016/j.bpj.2012.03.063. PubMed PMID: 22824272; PubMed Central PMCID: PMC3341537.
Cheheltani R, Rosano JM, Wang B, Sabri AK, Pleshko N, Kiani MF. Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction. J Biomed Opt. 2012 May;17(5):056014. doi: 10.1117/1.JBO.17.5.056014. PubMed PMID: 22612137; PubMed Central PMCID: PMC3381018.
Prabhakarpandian B, Shen MC, Pant K, Kiani MF. Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Microvasc Res. 2011 Nov;82(3):210-20. doi: 10.1016/j.mvr.2011.06.013. Epub 2011 Jul 2. Review. PubMed PMID: 21763328; PubMed Central PMCID: PMC3215799.
Prabhakarpandian B, Wang Y, Rea-Ramsey A, Sundaram S, Kiani MF, Pant K. Bifurcations: focal points of particle adhesion in microvascular networks. Microcirculation. 2011 Jul;18(5):380-9. doi: 10.1111/j.1549-8719.2011.00099.x. PubMed PMID: 21418388; PubMed Central PMCID: PMC3128654.
Bhattacharjee H, Nadipuram A, Kosanke S, Kiani MF, Moore BM 2nd. Low-volume binary drug therapy for the treatment of hypovolemia. Shock. 2011 Jun;35(6):590-6. doi: 10.1097/SHK.0b013e3182150e80. PubMed PMID: 21330941.
Tousi N, Wang B, Pant K, Kiani MF, Prabhakarpandian B. Preferential adhesion of leukocytes near bifurcations is endothelium independent. Microvasc Res. 2010 Dec;80(3):384-8. doi: 10.1016/j.mvr.2010.07.001. Epub 2010 Jul 21. PubMed PMID: 20624406; PubMed Central PMCID: PMC2981676.
Wang B, Rosano JM, Cheheltani R, Achary MP, Kiani MF. Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer. Expert Opin Drug Deliv. 2010 Oct;7(10):1159-73. doi: 10.1517/17425247.2010.513968. Review. PubMed PMID: 20738211.
Rosano JM, Tousi N, Scott RC, Krynska B, Rizzo V, Prabhakarpandian B, Pant K, Sundaram S, Kiani MF. A physiologically realistic in vitro model of microvascular networks. Biomed Microdevices. 2009 Oct;11(5):1051-7. doi: 10.1007/s10544-009-9322-8. Epub 2009 May 19. PubMed PMID: 19452279; PubMed Central PMCID: PMC2888702.
Scott RC, Rosano JM, Ivanov Z, Wang B, Chong PL, Issekutz AC, Crabbe DL, Kiani MF. Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J. 2009 Oct;23(10):3361-7. doi: 10.1096/fj.08-127373. Epub 2009 Jun 17. PubMed PMID: 19535683.
Pattillo CB, Venegas B, Donelson FJ, Del Valle L, Knight LC, Chong PL, Kiani MF. Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors. Pharm Res. 2009 May;26(5):1093-100. doi: 10.1007/s11095-009-9826-1. Epub 2009 Jan 27. PubMed PMID: 19172383.
Prabhakarpandian B, Pant K, Scott RC, Pattillo CB, Irimia D, Kiani MF, Sundaram S. Synthetic microvascular networks for quantitative analysis of particle adhesion. Biomed Microdevices. 2008 Aug;10(4):585-95. doi: 10.1007/s10544-008-9170-y. PubMed PMID: 18327641; PubMed Central PMCID: PMC4476637.
Scott RC, Crabbe D, Krynska B, Ansari R, Kiani MF. Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue. Expert Opin Drug Deliv. 2008 Apr;5(4):459-70. doi: 10.1517/17425247.5.4.459. Review. PubMed PMID: 18426386.
Siddiqui K, Del Valle L, Morellet N, Cui J, Ghafouri M, Mukerjee R, Urbanska K, Fan S, Pattillo CB, Deshmane SL, Kiani MF, Ansari R, Khalili K, Roques BP, Reiss K, Bouaziz S, Amini S, Srinivasan A, Sawaya BE. Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin. Oncogene. 2008 Jan 3;27(1):32-43. doi: 10.1038/sj.onc.1210632. Epub 2007 Jul 23. PubMed PMID: 17653096; NIHMSID:NIHMS228669.
Wang B, Scott RC, Pattillo CB, Prabhakarpandian B, Sundaram S, Kiani MF. Modeling oxygenation and selective delivery of drug carriers post-myocardial infarction. Adv Exp Med Biol. 2008;614:333-43. doi: 10.1007/978-0-387-74911-2_37. PubMed PMID: 18290344.
Wang B, Scott RC, Pattillo CB, Prabhakarpandian B, Sundaram S, Kiani MF. Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3732-9. doi: 10.1152/ajpheart.00735.2007. Epub 2007 Oct 19. PubMed PMID: 17951368.
Scott RC, Wang B, Nallamothu R, Pattillo CB, Perez-Liz G, Issekutz A, Del Valle L, Wood GC, Kiani MF. Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction. Biotechnol Bioeng. 2007 Mar 1;96(4):795-802. doi: 10.1002/bit.21233. PubMed PMID: 17051598.
Ansari R, Gaber MW, Wang B, Pattillo CB, Miyamoto C, Kiani MF. Anti-TNFA (TNF-alpha) treatment abrogates radiation-induced changes in vacular density and tissue oxygenation. Radiat Res. 2007 Jan;167(1):80-6. doi: 10.1667/rr0616.1. PubMed PMID: 17243316.
Yuan H, Gaber MW, Boyd K, Wilson CM, Kiani MF, Merchant TE. Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):860-6. doi: 10.1016/j.ijrobp.2006.06.043. PubMed PMID: 17011458.
Nallamothu R, Wood GC, Kiani MF, Moore BM, Horton FP, Thoma LA. A targeted liposome delivery system for combretastatin A4: formulation optimization through drug loading and in vitro release studies. PDA J Pharm Sci Technol. 2006 May-Jun;60(3):144-55. PubMed PMID: 17089683.
Nallamothu R, Wood GC, Pattillo CB, Scott RC, Kiani MF, Moore BM, Thoma LA. A tumor vasculature targeted liposome delivery system for combretastatin A4: design, characterization, and in vitro evaluation. AAPS PharmSciTech. 2006 Apr 7;7(2):E32. doi: 10.1208/pt070232. PubMed PMID: 16796350.
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