Innate immunity, cytokines, and pulmonary host defense

Infect Dis Clin North Am. 1998 Sep;12(3):555-67, vii. doi: 10.1016/s0891-5520(05)70198-7.

Abstract

Effective host defense against bacterial infection is dependent on the activation and recruitment of phagocytic cells. The initiation, maintenance, and resolution of this inflammatory response in the setting of bacterial pneumonia is dependent on the expression of cytokines. As the complexities of the host-pathogen interaction are further dissected and unraveled, immunologic manipulation of cytokine expression will likely become an important adjuvant therapy in the treatment of serious lung infections.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / metabolism
  • Bacterial Infections / immunology*
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Cytokines / therapeutic use
  • Disease Models, Animal
  • Granulocyte Colony-Stimulating Factor / immunology
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Immunity, Innate / immunology
  • Lung / immunology
  • Lung Diseases / immunology*
  • Macrophage Activation
  • Macrophages, Alveolar / immunology*
  • Neutrophils / immunology*
  • Neutrophils / metabolism
  • Pneumonia, Bacterial / immunology
  • Pneumonia, Bacterial / microbiology
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Bacterial Agents
  • Cytokines
  • Tumor Necrosis Factor-alpha
  • Granulocyte Colony-Stimulating Factor