Dielectric microspheres enhance microscopy resolution mainly due to increasing the effective numerical aperture

Light Sci Appl. 2023 Jan 11;12(1):22. doi: 10.1038/s41377-022-01056-4.

Abstract

Microsphere-assisted microscopy utilizing a microsphere in immediate proximity of the specimen boosts the imaging resolution mainly as a result of an increase in the effective numerical aperture of the system.