Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission

Kimberly Schmitt; James Curlin; Leila Remling-Mulder; Ryan Moriarty; Kelly Goff; Shelby O'Connor; Mark Stenglein; Preston Marx; Ramesh Akkina

doi:10.1111/jmp.12485

Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission

J Med Primatol. 2020 Oct;49(5):284-287. doi: 10.1111/jmp.12485. Epub 2020 Aug 17.

Authors

Kimberly Schmitt¹, James Curlin¹, Leila Remling-Mulder¹, Ryan Moriarty², Kelly Goff³, Shelby O'Connor², Mark Stenglein¹, Preston Marx^{3

4}, Ramesh Akkina¹

Affiliations

¹ Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA.
² University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
³ Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
⁴ Tulane National Primate Research Center, Covington, LA, USA.

Abstract

HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4⁺ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.

Keywords: Cross‐species SIV transmission; HIV‐1 viral evolution from SIV; SIV chimpanzee evolution toward HIV‐1; SIVcpz infection in humanized mice; hu‐HSC mice for cross‐species viral transmission.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Ape Diseases / virology*
Disease Models, Animal
Evolution, Molecular
HIV-1 / genetics*
Mutation*
Pan troglodytes*
Simian Immunodeficiency Virus / genetics*

Abstract

Publication types

MeSH terms

Grants and funding