Abstract
In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6]-shogaol exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol inhibited the Ca²⁺-dependent contractions in high K⁺ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta / drug effects
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Aorta / physiology
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Catechols / chemistry
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Catechols / isolation & purification
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Fatty Alcohols
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In Vitro Techniques
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Platelet Aggregation Inhibitors / isolation & purification
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Platelet Aggregation Inhibitors / pharmacology*
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Rabbits
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Rats
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Rhizome / chemistry*
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Structure-Activity Relationship
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Vasodilation / drug effects
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Vasodilator Agents / isolation & purification
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Vasodilator Agents / pharmacology*
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Zingiber officinale / chemistry*
Substances
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Catechols
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Fatty Alcohols
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O-methyldehydrogingerol
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Plant Extracts
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Platelet Aggregation Inhibitors
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Vasodilator Agents
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gingerol