Abstract
New phenyl adenine compounds 5-7 were synthesized as analogues of adenosine and studied for their adenosine deaminase (ADA) substrate activity. The 9-[(o-hydroxymethyl)phenyl]methyl]adenine 5 and 9-[(m-hydroxymethyl)phenyl]adenine 7 were deaminated by ADA, and 9-[(o-hydroxyethyl)phenyl]adenine 6 was not deaminated up to 7 days. The ADA substrates 5 and 7 were deaminated quantitatively to their inosine analogues in 10 and 6h, respectively.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / metabolism
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Adenosine Deaminase / metabolism*
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Animals
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Cattle
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Chromatography, Thin Layer
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Deamination / drug effects
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Inosine / analogs & derivatives
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Inosine / metabolism
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Intestines / enzymology
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Magnetic Resonance Spectroscopy
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Purines / metabolism
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Spectrophotometry, Ultraviolet
Substances
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Purines
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Inosine
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Adenosine Deaminase
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Adenosine
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purine