Approximately 15% of cancers diagnosed were attributed to carcinogenic viral infections. Upon viral infections, the host innate immune system acts as the first line of defense to prevent viral invasion or replication, while viruses also strive for survival by repressing innate immune signaling. By further understanding how innate immunity is regulated by tumor viruses, our lab aims to dissect the interactions between innate immune responses and viral tumor development. Our long term goal is to identify potential targets and strategies for viral cancer treatment.